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- DIFFERENT METHODS OF ENHANCEMENT OF SOLUBILIZATION AND BIOAVAILABILITY OF POORLY SOLUBLE DRUGS: A RECENT REVIEW
- EVALUATION OF ANTHELMINTIC ACTIVITY OF ETHANOLIC ROOT EXTRACT OF ALLOPHYLUS SERRATUS.
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Pondicherry Centre for Biological Sciences (PCBS) is an Indian private R&D organization founded with an aim to promote research in the field of molecular infection and immunology. We are fore-runners to establish such research oriented centers in Pondicherry.
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About Authors:
Patel Chirag J*, Asija Rajesh, Asija Sangeeta
Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics,
Jaipur, Rajasthan.
*chirag.bangalore@gmail.com
Patel Chirag J*, Asija Rajesh, Asija Sangeeta
Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics,
Jaipur, Rajasthan.
*chirag.bangalore@gmail.com
ABSTRACT
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. This review discusses BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement.Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropy method, use of salt forms, solvent deposition, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers.Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.With the advent of combinatorial chemistry and a high throughput screening, the number of poorly water soluble compounds has increased solubility. A success of formulation depends on how efficiently it makes the drug available at the site of action.The purpose of this review article is to describe the techniques of solubilization for the attainment of effective absorption with improved bioavailability.
Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. This review discusses BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement.Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropy method, use of salt forms, solvent deposition, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers.Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.With the advent of combinatorial chemistry and a high throughput screening, the number of poorly water soluble compounds has increased solubility. A success of formulation depends on how efficiently it makes the drug available at the site of action.The purpose of this review article is to describe the techniques of solubilization for the attainment of effective absorption with improved bioavailability.
About Authors:A.SRILAKSHMI*, AMRUTHA R.E, N.KRISHNA SREE
Department of Pharmacology
P. Rami Reddy Memorial College of Pharmacy,
Andhra Pradesh, India.
*amrutharamapuram@gmail.com
Department of Pharmacology
P. Rami Reddy Memorial College of Pharmacy,
Andhra Pradesh, India.
*amrutharamapuram@gmail.com
Abstract:
Present study was aimed to evaluate the anthelmentic activity of ethanolic extract of Allophylus serratus against Indian earthworms Pheritima posthuma. The various concentrations of ehanolic extract of Allophylus serratus were tested for paralysis time and death time of the worms. Results revealed that all the concentrations of Allophylus serratus possess anthelmentic activity in a dose dependant manner. Potency of the test samples was found to be inversely proportional to the time taken for paralysis/death of the worms. The activities were comparable with the reference drug Albendazole(20mg/ml). Among the various concentrations of extracts 400mg/ml dose was found to possess promising anthelmentic activity in comparison to other extracts like 100mg/ml,200mg/ml. Phyto constituents of ethanolic extract of Allophylus serratus were found to be Flavonoids, Phenolic compounds,steroids,tri-terpenoids, Glycosides. The present study therefore justifies its use in the folklore remedies as an anthelmentic drug of natural origin.
Present study was aimed to evaluate the anthelmentic activity of ethanolic extract of Allophylus serratus against Indian earthworms Pheritima posthuma. The various concentrations of ehanolic extract of Allophylus serratus were tested for paralysis time and death time of the worms. Results revealed that all the concentrations of Allophylus serratus possess anthelmentic activity in a dose dependant manner. Potency of the test samples was found to be inversely proportional to the time taken for paralysis/death of the worms. The activities were comparable with the reference drug Albendazole(20mg/ml). Among the various concentrations of extracts 400mg/ml dose was found to possess promising anthelmentic activity in comparison to other extracts like 100mg/ml,200mg/ml. Phyto constituents of ethanolic extract of Allophylus serratus were found to be Flavonoids, Phenolic compounds,steroids,tri-terpenoids, Glycosides. The present study therefore justifies its use in the folklore remedies as an anthelmentic drug of natural origin.
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