Science Job Updates
- Walk in interview as Pharmacist at ONGC - 6 posts
- Application invited as Lecturer and Non-Faculty vacancies in NIPER - 17 posts
- Advanced Enzymes Technologies invites for Sales/Marketing Executive - API marketing
- Work as Head, Regulatory Affairs in Pfizer India
- FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF NIFEDIPINE
ONGC ranks as the Numero Uno Oil & Gas Exploration & Production (E&P) Company in the world, as per Platts 250 Global Energy Companies List for the year 2008 based on assets, revenues, profits and return on invested capital (ROIC).
ONGC ranks 20th among the Global publicly-listed Energy companiesas per ‘PFC Energy 50”
ONGC ranks 20th among the Global publicly-listed Energy companiesas per ‘PFC Energy 50”
Post: Pharmacist (on contract)
NIPER, Rae Bareli at ITI campus, Rae Bareli under the mentoring Institute of Central Drug Research Institute, Lucknow invites application for following positions on purely temporary basis on contract initially for a period of 1 year which can be extended further for another year on the existing terms and conditions of the offer. The selected candidates shall have no claim for regularization implicitly / explicitly against any regular post either in NIPER or CDRI.
With a history spanning more than half a century, Advanced Enzymes Technologies Ltd (Advanced Enzymes) has emerged as a worldwide leader in the production of plant, microbial and animal-based enzymes. In 1957, our founder, Mr. L.C. Rathi, pioneered the extraction of papain, an enzyme complex derived from papaya fruit and widely used for pharmaceutical and medical purposes. Since 1989, Advanced Enzymes has continued to grow with that same entrepreneurial and innovative spirit and today is the largest manufacturer of Enzymes in the Indian Sub-Continent.
Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.
About Authors:
*DINESH BABU GOTTIPATI1, SREE DEVI ANANDHAM1, NANNAPANENI VENKATA BALAKRISHNA RAO2.
1 Department of pharmaceutics, M.E.S.college of pharmacy, Aradeshally gate, Bangalore -562110,India.
2 Research and Development Department, Natco Pharma Limited, Kothur.
*babu.dinesh89@live.in
*DINESH BABU GOTTIPATI1, SREE DEVI ANANDHAM1, NANNAPANENI VENKATA BALAKRISHNA RAO2.
1 Department of pharmaceutics, M.E.S.college of pharmacy, Aradeshally gate, Bangalore -562110,India.
2 Research and Development Department, Natco Pharma Limited, Kothur.
*babu.dinesh89@live.in
ABSTRACT:
The aim of this study was to evaluate the effect of increasing nifedipine on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine were prepared by wet granulation technique using Crospovidone and croscarmellose sodium (CCS) as super disintegrants as super disintegrants, Flavor and sweetener impart the taste to the formulation. The porous granules were compressed in to tablets by 8mm punch rotary tablet machine. All the formulations were evaluated for weight variation, hardness, friability, content uniformity, wetting time, and disintegration time and dissolution rate. Among the formulations, F9 one containing to be the best acceptable in terms of palatability, fast dissolving tablet having adequate strength. The disintegration time was found to be 56 ± 0.4 seconds, hardness of 4.6 ± g /cm2, wetting time of 31sec and drug release of 99.85 % in 9 mins. All the formulations showed low weight variation. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
The aim of this study was to evaluate the effect of increasing nifedipine on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine were prepared by wet granulation technique using Crospovidone and croscarmellose sodium (CCS) as super disintegrants as super disintegrants, Flavor and sweetener impart the taste to the formulation. The porous granules were compressed in to tablets by 8mm punch rotary tablet machine. All the formulations were evaluated for weight variation, hardness, friability, content uniformity, wetting time, and disintegration time and dissolution rate. Among the formulations, F9 one containing to be the best acceptable in terms of palatability, fast dissolving tablet having adequate strength. The disintegration time was found to be 56 ± 0.4 seconds, hardness of 4.6 ± g /cm2, wetting time of 31sec and drug release of 99.85 % in 9 mins. All the formulations showed low weight variation. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
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